Steroidal Glycosides of Cordyline australis

摘要: The n-butanol extract of aerial parts Cordyline australis demonstrated antifungal activity. n-Butanol and chloroform extracts dried or fresh leaves C. afforded a steroidal glycoside, which was identified as 5α-spirost-25(27)-en-3β-ol 3-O{O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside}, saponin 1. This spirostanol glycoside showed strong activity towards Trichophyton mentagrophytes some aspecific cytotoxicity against MRC5 cell. The yielded second new 5α-spirost-25(27)-ene-1β,3β-diol 1-{O-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside}, 2. senescent third that 1-{O-β-D- fucopyranoside, 3. A mixture two isomeric flavonoid glycosides isolated from shown to be ca 1:1 isorhamnetin-3-O-{O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside}, 4 isorhamnetin-3-O-{O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside}, 5. Three other known glycosides, β-sitosterol glucoside, 6, prosapogenin A dioscin, 7, trillin, 8 were also the australis. stems (25S)-5α-spirostane-1β,3α-diol 1-{O-β-D-glucopyranoside}, 9. moderate Herpes simplex type I virus (ATCC VR733) Polio Virus Type (Pfiser vaccine strain).