Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines.
作者： Weiqun Wang , Peter C. VanAlstyne , Kimberly A. Irons , She Chen , Jeanne W. Stewart
DOI: 10.1207/S15327914NC4801_14
关键词:
摘要: Apigenin has been previously shown to induce G2/M cell-cycle arrest in human colon cancer cell lines. The present study assessed the individual and interactive influence of seven apigenin analogs on cycle, number, viability SW480 Caco-2 colonic carcinoma cells. Cellular concentration selected was further by high-performance liquid chromatography assess cellular availability. studied were acacetin, chrysin, kampherol, luteolin, myricetin, naringenin, quercetin. DNA flow cytometric analysis indicated that treatment with either chrysin or acacetin at 0 80 μM for 48 h resulted phase a dose-dependent manner cells but not percentage also increased when treated quercetin between 5 30 μM, decreased doses greater than 40 μM. Cell number signif...
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