Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids.
作者： S.J. Lee , J.H. Choi , K.H. Son , H.W. Chang , S.S. kang
DOI: 10.1016/0024-3205(95)00305-P
关键词: Biflavonoids 、 Amentoflavone 、 Lymphocyte 、 Biochemistry 、 Lymphocyte proliferation 、 Pharmacology 、 Flavones 、 Ochnaflavone 、 Apigenin 、 Chemistry 、 Quercetin
摘要: Abstract In a continuing effort to investigate biological activities of flavonoids, nine biflavonoids, isolated from three plant sources were evaluated for their suppressive effects on mouse lymphocyte proliferation. The biflavonoids tested amentoflavone, bilobetin, ginkgetin, isoginkgetin, sciadopitysin, ochnaflavone, 4'-O-methylochnaflavone, cryptomerin B and isocryptomerin At 10 μM, several such as showed the activity against proliferation induced by Con A or LPS. Apigenin (flavone) quercetin (flavonol) A-induced proliferation, but not LPS-induced at same concentration range. Biflavonoids found be irreversible inhibitors This is first report describing naturally-occurring
elsevier.com
sci-hub.se 参考文章(15)
Patrice C. Ferriola, Vivian Cody, Elliott Middleton, Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochemical Pharmacology. ,vol. 38, pp. 1617- 1624 ,(1989) , 10.1016/0006-2952(89)90309-2
S.Y. Namgoong, K.H. Son, H.W. Chang, S.S. Kang, H.P. Kim, Effects of naturally occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture Life Sciences. ,vol. 54, pp. 313- 320 ,(1994) , 10.1016/0024-3205(94)00787-X
C. Bronner, Y. Landry, Kinetics of the inhibitory effect of flavonoids on histamine secretion from mast cells. Inflammation Research. ,vol. 16, pp. 147- 151 ,(1985) , 10.1007/BF01983124
M. Ruckstuhl, A. Beretz, R. Anton, Y. Landry, Flavonoids are selective cyclic GMP phosphodiesterase inhibitors. Biochemical Pharmacology. ,vol. 28, pp. 535- 538 ,(1979) , 10.1016/0006-2952(79)90249-1
H.W. Chang, S.H. Baek, K.W. Chung, K.H. Son, H.P. Kim, S.S. Kang, Inactivation of phospholipase A2 by naturally occurring biflavonoid, ochnaflavone. Biochemical and Biophysical Research Communications. ,vol. 205, pp. 843- 849 ,(1994) , 10.1006/BBRC.1994.2741
Yuh-Meei Lin, Fa-Ching Chen, Kuo-Hsiung Lee, Hinokiflavone, a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavonoids. Planta Medica. ,vol. 55, pp. 166- 168 ,(1989) , 10.1055/S-2006-961914
A. Beretz, M. Joly, J. Stoclet, R. Anton, Inhibition of 3',5'-AMP phosphodiesterase by biflavonoids and xanthones. Planta Medica. ,vol. 36, pp. 193- 195 ,(1979) , 10.1055/S-0028-1097268
Ching-Jer Chang, Robert L. Geahlen, Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. Journal of Natural Products. ,vol. 55, pp. 1529- 1560 ,(1992) , 10.1021/NP50089A001
Maurice M. Iwu, Ogo A. Igboko, Chris O. Okunji, Michael S. Tempesta, Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola Journal of Pharmacy and Pharmacology. ,vol. 42, pp. 290- 292 ,(2011) , 10.1111/J.2042-7158.1990.TB05412.X
Vivian. Cody, Plant flavonoids in biology and medicine II Meeting on Plant Flavonoids in Biology and Medicine (1987 : Strasbourg, France). ,(1988)