Investigation of the efficacy of a genetically-stabile live Salmonella typhimurium vaccine for use in swine

摘要: Hybrid swine (Landrace x Pietrain) aged 3-4 weeks were immunized twice at an interval of 3 solely by the oral route and oral/parenteral to evaluate efficacy a live S. Typhimurium vaccine. In each experiment control group was run without vaccination. The animals challenged age 8-10 test infection with labelled DT 104 strain. An ELISA used establish presence antibodies in serum samples, coupled clinical investigation. challenge strain ileal caecal mucosa ileocolic lymph nodes investigated quantitatively using Koch plating method determine degree colonization those organs time slaughter. course disease assess success However, it not possible trigger, reproducible manner, signs unvaccinated through infection. vaccinated had significantly lower (p < 0.05) than animals. This also seen lesser for nodes.