Vaccination of pregnant ewes against infection with Salmonella Brandenburg.

摘要: Abstract AIMS: To develop a challenge model for Salmonella Brandenburg infection in pregnant ewes. compare efficacies of live attenuated Typhimurium mutant, subunit preparation from virulent S. isolate, and commercial multivalent inactivated vaccine their ability to prevent experimental infection. assess the efficacy mutant against natural lambs. METHODS: Two-year-old ewes were immunised with either (eye-drop; n=20), (n=20) or an bacterin (n=20), both administered subcutaneously, served as unvaccinated controls (n=21). Four weeks later, sensitising regime was repeated booster vaccination, challenged 6 later approximately prior lambing. The presence clinical signs, abortion death noted following challenge. number...