Effectiveness of Antibiotic Prophylaxis in Third Molar Surgery: A Meta-Analysis of Randomized Controlled Clinical Trials
作者： Yan-Fang Ren , Hans S. Malmstrom
DOI: 10.1016/J.JOMS.2007.03.004
关键词:
摘要: Purpose We conducted a synthetic quantitative review of the published clinical trials on effectiveness antibiotic prophylaxis in third molar surgery. Materials and Methods Electronic databases were searched for randomized controlled trials. The primary outcome variables included alveolar osteitis (AO) surgical wound infection. extracted data analyzed using meta-analytical program with random-effect model. Number needed to treat (NnT) was calculated. Results A total 2,932 patients 16 reported AO as an outcome. occurred 84 1,350 treatment group, frequency 6.2%; 228 1,582 control 14.4%. Systemic therapy effective reducing risk (odds ratio [OR], 2.175) NnT 13. 2,396 12 infection Wound 44 1,110 4%; 78 1,286 6.1%. (OR, 1.794) 25. Antibiotics reduced only when first dose given before Conclusions antibiotics surgery frequencies after
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