Nonenzymatic Isomerization of 9-CIS-Retinoic Acid Catalyzed by Sulfhydryl Compounds
作者： Tsu-Han Lin , Donald L. Hill , Tzu-Wen Shih , Y. Fulmer Shealy
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摘要: Certain thiol-containing compounds catalyze, in a chemical reaction, the isomerization of 9-cis-retinoic acid to mixture all-trans-retinoic acid, 13-cis-retinoic and 9,13-dicis-retinoic acid. In presence such catalysts, gives rise same mixture. Reactions approaching equilibrium contain more than either other isomers. Small molecules effective as catalysts are mercaptoethanol, L-cysteine methyl ester, glutathione, N-acetyl-L-cysteine. Apoferritin (a protein), native microsomes, and, lesser extent, boiled microsomes catalyze reaction. intact cells, these interconversions also occur process inhibited by sulfhydryl-specific reagent. The thiol-catalyzed may be relevant biological activity this compound.
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