In vivo isomerization of retinoic acids. Rapid isomer exchange and gene expression.
作者： R Kojima , T Fujimori , N Kiyota , Y Toriya , T Fukuda
DOI: 10.1016/S0021-9258(18)31691-0
关键词:
摘要: The in vivo isomerization of all-trans- and 9-cis-retinoic acids (RAs) was evaluated by high performance liquid chromatography after oral administration to rats. All-trans (2 ng/ml)- 13-cis (1.8 ng/ml)-RAs, but not 9-cis-RA, were detected the serum normal When an excess either all-trans-RA or 9-cis-RA (100 micrograms/rat) intragastrically administered retinoid-depleted rats, a rapid isomer exchange between 9-cis- all-trans-RAs along with appearance RA occurred shortly dose (30 min). rapidly isomerized when (1 mg/rat) To examine whether RAs elicit biological actions vivo, induction target genes-[cellular retinol-binding protein type II (CRBP II) for all-trans-retinoic acid receptor beta (RAR beta) all-trans-RAs] determined. degree two genes did differ 4 h all-trans-RA. However, unlike all-trans-RA, RAR-specific synthetic retinoids induce CRBP gene. These results suggested that apparent on gene expression may be mediated some extent converted stereoisomer.
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