Hat acetylation promoters and uses of compositions thereof in promoting immunogenicity
作者： Robyn P. Seipp , Rayshad Gopaul , Jennifer Hartikainen , Wilfred Arthur Jefferies , Muriel David
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摘要: The invention provides processes and compositions for enhancing the immunogenicity of TAP-1 expression-deficient cells by increasing presentation MHC Class I surface molecules detection cytotoxic T-lymphocyte through increased expression, which comprises administering to a expression amount bio-acceptable substance that promotes transcription gene in cause enhanced cells. may be histone H3 deacetylase inhibitor such as trichostatin A, transcriptional co-activator having intrinsic acetyl transferase activity or comprising at least one member CBP/p300 protein family. process increase target cells, e.g. tumor enhance their destruction lymphocytes.
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