The inhibition of ribonuclease by acidic polymers and their use as possible antiviral agents

摘要: Abstract 1. The anti-RNase activity of 66 acidic polymers largely synthetic origin has been investigated. In the test system used, activities half-inhibition at concentrations 1 μg./ml. in protein-free media were frequent. degree inhibition is decreased markedly by proteins, and to a varying but lesser extent salts, or increase pH. 2. Numerous other polymers, as well nonpolymeric substances, have similarly tested, with negative results almost all instances. 3. Among number highly active RNase inhibitors antiinfluenza antivaccinia eggs. possible relationship between virus embryonated eggs discussed.