Oxidative Stress and the Amyloid Conundrum. What is the Connection

摘要: In the sea of information for and against role amyloid in AD many us have felt at times akin circumstances. The hypothesis by Andorn Kalaria that peptides could function both as antioxidants pro-oxidants yet adds a new dimension complexity to an already intricate problem Alzheimer’s disease. These authors present evidence suggesting various Aβ fragments can, under certain experimental conditions, behave inhibiting ascorbate-induced lipid peroxidation membrane fragment preparations obtained from postmortem human prefrontal parietal cortex. findings raise interesting issues regarding deposits AD. During last few years several laboratories presented compelling indicating brains with are subject pervasive level oxidative stress. One important set data comes vitro models suggests peptide, main constituent senile plaques, causes extensive degeneration