Multifunctional snake C-type lectins affecting platelets.

摘要: Snake venoms contain a wide range of components, many which affect haemostasis by activation or inhibition platelets coagulation factors. They can be classified into groups based on structure and mode action. One group is the snake C-type lectins, so called because typical folding closely resembles that found in classical such as selectins mannose-binding proteins. Unlike classic those from snakes are generally heterodimeric with two subunits, β. Some multimeric heterodimers. The subunits have homologous sequences linked disulphide bond well swapping loops. first lectins defined function was echicetin demonstrated to bind platelet GPIb block several functions this receptor. Since then, proteins similar been reported act receptors factors crystallized. These were thought specific for single receptor factor, i.e. they had only one per heterodimer. Recent studies show most these binding sites more than ligand complex mechanisms