When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer.

摘要: Since the discovery of leptin in 1994, our vision adipose tissue as a static organ regulating mainly lipid storage and release has been completely overthrown, is now seen an active integral human physiology. In past years, extensive research tremendously given us more insights mechanisms pathways involved not only normal but also 'sick' tissue, for example, obesity lipodystrophy. With growing evidence link between several types cancer, focusing on interaction cancer begun to unravel interesting complex multi-lateral communication different players. breast one first where positive correlation incidence prognosis post-menopausal women was found, we have focused this review paracrine endocrine role initiation progression. As important inter-species differences occur, selected tissue- cancer-based studies with short reflection therapeutic possibilities. This part special issue "Adiposopathy Cancer (Cardio)Metabolic Diseases".