In vitro and in vivo antimicrobial properties of silver-containing hydroxyapatite prepared via ultrasonic spray pyrolysis route

摘要: Hydroxyapatite (HAp), with its high biocompatibility and osteoconductivity, readily absorbs proteins, amino acids other substances, which in turn favor the adsorption colonization of bacteria. To prevent bacterial growth biofilm formation on HAp discs, silver-containing (1-20 mol%) (Ag-HAp) powders were synthesized using an ultrasonic spray pyrolysis (USSP) technique. The X-ray diffraction (XRD) peaks very broad, indicating low crystallinity, this induced release Ag(+) ions from Ag-HAp powders. In addition, a gradual increase Ca(2+) ion was observed. These results suggest that dissolution triggered ions. antimicrobial efficacy disc tested against Staphylococcus aureus. Samples Ag contents more than 5 mol% found to be highly effective vitro. vivo antibacterial tests bioluminescent strains also showed reductions viability bacteria (5 discs. Biocompatibility modified Transwell® insert method discs have negative effects osteoblast proliferation. indicate has activity good both vitro together biocompatibility, thus confirming utility as bactericidal material.