Bioactive 3,4-seco-Triterpenoids from the Fruits of Acanthopanax sessiliflorus.
作者： Dae-Young Lee , Kyeong-Hwa Seo , Dong-Sung Lee , Youn-Chul Kim , In-Sik Chung
DOI: 10.1021/NP3002173
关键词:
摘要: Eight new 3, 4-seco-lupane triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A–F (2, 4–8), as well as six known 3, 4-seco-lupane triterpenes (9–14) were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures of 1–8 were determined by spectroscopic data interpretation. All isolated compounds were tested for their cytotoxicity against six human cancer cell lines and their ability to inhibit LPS-induced nitric oxide production in RAW 264.7 macrophages.
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