Human T Lymphocyte Subpopulations: Studies of the Mechanism by Which T Cells Bearing Fc Receptors for IgG Suppress T-Dependent B Cell Differentiation Induced by Pokeweed Mitogen

摘要: The mechanism by which human T lymphocytes bearing receptors for IgG (TG cells) suppress B cell differentiation promoted pokeweed mitogen (PWM) and helper TM cells was studied. In this model system, autologous TG were shown to via soluble factors released without detectable proliferation. order release these factors, needed interact with PWM in addition their reaction immune complexes during the isolation procedure. Suppression occurred only when added early mixtures of cultured presence PWM. appeared be resistant suppression under a variety experimental conditions. “preactivated” differentiated into plasma any further help cells. re-isolated from 2-day cultures containing cells, retained capacity differentiate induced supernatants activated or factors. When preincubated suppressor supernatants, ability induce reduced; contrast, similar pretreatment had no effect on differentiation. These results suggest that can induction polyclonal acting indirectly