Associations between Serum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study
作者： Gareth J. McKay , Ian S. Young , Ann McGinty , Graham C.G. Bentham , Usha Chakravarthy
DOI: 10.1016/J.OPHTHA.2016.09.007
关键词:
摘要: Purpose To study associations between early and late age-related macular degeneration (AMD) neovascular AMD (nvAMD) with serum 25-hydroxy vitamin D (25(OH)D) genetic variants in pathway genes. Design Population-based, cross-sectional a random sample aged 65 years or older from 7 European countries. Participants Of 4753 participants, 4496 (2028 men 2468 women), mean age of 73 years, provided blood sample; 2137 had no signs AMD, 2209 150 whom 104 nvAMD. Methods were interviewed to determine smoking alcohol use, sunlight exposure, diet; underwent fundus photography. Fundus images graded using the International Classification System for Age-Related Maculopathy. The 25(OH)D was measured by liquid chromatography–tandem mass spectrometry categorized as deficient ( Main Outcome Measures Adjusted odds ratio (OR) 3 outcomes (early nvAMD). Results No linear association found There insufficient status AMD. Deficient associated nvAMD (adjusted OR, 1.27; 95% confidence interval, 1.1–1.45; P GC , VDR CYP2R1 CYP27B1 . Two SNPs ) 4 RXRA 1 SNP nvAMD, ), 2 After Bonferroni correction, Conclusions Deficiency but adjusted OR small, we cannot exclude residual confounding. hypothesis causal is not supported clear evidence an
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Peter J.A. Davies, L. Nagy, A. Szanto, H. S. Ahuja, The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death Journal of Biological Regulators and Homeostatic Agents. ,vol. 17, pp. 29- 45 ,(2003)
Heather B Del Valle, A Catharine Ross, Ann L Yaktine, Christine L Taylor, Dietary Reference Intakes for Calcium and Vitamin D ,(2013)
W C Willett, G R Howe, L H Kushi, Adjustment for total energy intake in epidemiologic studies The American Journal of Clinical Nutrition. ,vol. 65, ,(1997) , 10.1093/AJCN/65.4.1220S
Audrey Cougnard-Grégoire, Bénédicte MJ Merle, Jean-Francois Korobelnik, Marie-Bénédicte Rougier, Marie-Noëlle Delyfer, Catherine Féart, Mélanie Le Goff, Jean-François Dartigues, Pascale Barberger-Gateau, Cécile Delcourt, Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration Journal of Nutrition. ,vol. 145, pp. 1865- 1872 ,(2015) , 10.3945/JN.115.214387
Amy E. Millen, Kristin J. Meyers, Zhe Liu, Corinne D. Engelman, Robert B. Wallace, Erin S. LeBlanc, Lesley F. Tinker, Sudha K. Iyengar, Jennifer G. Robinson, Gloria E. Sarto, Julie A. Mares, Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk JAMA Ophthalmology. ,vol. 133, pp. 1171- 1179 ,(2015) , 10.1001/JAMAOPHTHALMOL.2015.2715
Don H. Anderson, Monte J. Radeke, Natasha B. Gallo, Ethan A. Chapin, Patrick T. Johnson, Christy R. Curletti, Lisa S. Hancox, Jane Hu, Jessica N. Ebright, Goldis Malek, Michael A. Hauser, Catherine Bowes Rickman, Dean Bok, Gregory S. Hageman, Lincoln V. Johnson, The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Progress in Retinal and Eye Research. ,vol. 29, pp. 95- 112 ,(2010) , 10.1016/J.PRETEYERES.2009.11.003
W. Chen, D. Stambolian, A. O. Edwards, K. E. Branham, M. Othman, J. Jakobsdottir, N. Tosakulwong, M. A. Pericak-Vance, P. A. Campochiaro, M. L. Klein, P. L. Tan, Y. P. Conley, A. Kanda, L. Kopplin, Y. Li, K. J. Augustaitis, A. J. Karoukis, W. K. Scott, A. Agarwal, J. L. Kovach, S. G. Schwartz, E. A. Postel, M. Brooks, K. H. Baratz, W. L. Brown, A. J. Brucker, A. Orlin, G. Brown, A. Ho, C. Regillo, L. Donoso, L. Tian, B. Kaderli, D. Hadley, S. A. Hagstrom, N. S. Peachey, R. Klein, B. E. K. Klein, N. Gotoh, K. Yamashiro, F. Ferris, J. A. Fagerness, R. Reynolds, L. A. Farrer, I. K. Kim, J. W. Miller, M. Corton, A. Carracedo, M. Sanchez-Salorio, E. W. Pugh, K. F. Doheny, M. Brion, M. M. DeAngelis, D. E. Weeks, D. J. Zack, E. Y. Chew, J. R. Heckenlively, N. Yoshimura, S. K. Iyengar, P. J. Francis, N. Katsanis, J. M. Seddon, J. L. Haines, M. B. Gorin, G. R. Abecasis, A. Swaroop, R. N. Johnson, E. Ai, H. R. McDonald, M. Stolarczuk, P. R. Pavan, K. K. Billiris, M. Iyer, M. M. Menosky, S. E. Pautler, S. M. Millard, B. Hubbard, T. Aaberg, L. DuBois, A. Lyon, S. Anderson-Nelson, L. M. Jampol, D. V. Weinberg, A. Munana, Z. Rozenbajgier, D. Orth, J. Cohen, M. MacCumber, M. MacCumber, C. Figliulo, L. Porcz, J. Folk, H. C. Boldt, S. R. Russell, R. Ivins, C. J. Hinz, C. C. Barr, S. Bloom, K. Jaegers, B. Kritchman, G. Whittington, J. Heier, A. R. Frederick, M. G. Morley, T. Topping, H. L. Davis, S. B. Bressler, N. M. Bressler, W. Doll, M. Trese, A. Capone, B. R. Garretson, T. S. Hassan, A. J. Ruby, T. Osentoski, C. A. McCannel, M. J. Ruszczyk, G. Grand, K. Blinder, N. M. Holekamp, D. P. Joseph, G. Shah, G. S. Nobel, A. N. Antoszyk, D. J. Browning, A. H. Stallings, L. J. Singerman, D. Miller, M. Novak, S. Pendergast, H. Zegarra, S. A. Schura, S. Smith-Brewer, F. H. Davidorf, R. Chambers, L. Chorich, J. Salerno, R. F. Dreyer, C. Ma, M. R. Kopfer, M. L. Klein, D. J. Wilson, S. K. Nolte, J. E. Grunwald, A. J. Brucker, J. Dunaief, S. L. Fine, A. M. Maguire, R. A. Stoltz, M. N. McRay, G. E. Fish, R. Anand, R. Spencer, J. Arnwine, S. R. Chandra, M. Altaweel, B. Blodi, J. Gottlieb, M. Ip, T. M. Nork, J. Perry-Raymond, S. L. Fine, M. G. Maguire, M. Brightwell-Arnold, S. Harkins, E. Peskin, G.-S. Ying, N. Kurinij, , Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 7401- 7406 ,(2010) , 10.1073/PNAS.0912702107
Igor Bendik, Angelika Friedel, Franz F. Roos, Peter Weber, Manfred Eggersdorfer, Vitamin D: a critical and essential micronutrient for human health Frontiers in Physiology. ,vol. 5, pp. 248- 248 ,(2014) , 10.3389/FPHYS.2014.00248
S. Karami, P. Brennan, M. Navratilova, D. Mates, D. Zaridze, V. Janout, H. Kollarova, V. Bencko, V. Matveev, N. Szesznia-Dabrowska, I. Holcatova, M. Yeager, S. Chanock, N. Rothman, P. Boffetta, W-H. Chow, L. E. Moore, Vitamin D pathway genes, diet, and risk of renal cell carcinoma International Journal of Endocrinology. ,vol. 2010, pp. 879362- 879362 ,(2010) , 10.1155/2010/879362
Paul D. Loprinzi, Bonnielin K. Swenor, Pradeep Y. Ramulu, Age-Related Macular Degeneration Is Associated with Less Physical Activity among US Adults: Cross-Sectional Study. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0125394