Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk

摘要: Importance Deficient 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with increased odds of age-related macular degeneration (AMD). Objective To examine whether this association is modified by genetic risk for AMD and there an between single-nucleotide polymorphisms genes involved in vitamin transport, metabolism, genomic function. Design, Setting, Participants Postmenopausal women (N = 913) who were participants the Carotenoids Age-Related Eye Disease Study (CAREDS) (aged 54 to Main Outcomes Measures Prevalent early or late was determined from graded, stereoscopic fundus photographs. Logistic regression used estimate ratios (ORs) 95% CIs joint effects 25(OH)D ( Results Among 913 women, 550 had adequate levels (≥20 ng/mL), 275 inadequate (≥12 CFH Y402H (SI additive interaction, 1.4; CI, 1.1-1.7; P multiplicative interaction = .25). Significant (SI, 1.4; CI, 1.1-1.7) interactions  = .02) observed deficient 2 high-risk CFI (rs10033900) alleles (OR, 6.3; CI, 1.6-24.2). The did not differ genotype candidate genes. Conclusions Relevance In study, highest those status genotypes, suggesting a synergistic effect complement cascade protein Limited sample size led wide CIs. Findings may be due chance explained residual confounding.