Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration

摘要: Purpose Unhealthy lifestyles have been associated with increased odds for age-related macular degeneration (AMD). Whether this association is modified by genetic risk AMD unknown and was investigated. Design Interactions between healthy genotypes were studied in relation to the prevalence of AMD, assessed 6 years later. Participants Women 50 79 age Carotenoids Age-Related Eye Disease Study exposure data (n = 1663). Methods Healthy lifestyle scores (0–6 points) assigned based on Eating Index scores, physical activity (metabolic equivalent task hours/week), smoking pack 1994 1998. Genetic Y402H complement factor H ( CFH ) A69S maculopathy susceptibility locus 2 ARMS2 ). Additive multiplicative interactions ratios using synergy index a interaction term, respectively. Main Outcome Measures presence severity from grading stereoscopic fundus photographs taken 2001–2004. present 337 women, 91% whom had early AMD. Results The 3.3 times greater (95% confidence interval [CI], 1.8-6.1) women both low score (0–2) high-risk genotype (CC), relative those who (TT) high (4–6). There no significant additive (synergy [SI], 1.08; 95% CI, 0.70–1.67) or P  = 0.94) full sample. However, when limiting sample stable diets before assessment 728) strengthened (odds ratio, 4.6; 1.8–11.6) (SI, 1.34; 1.05–1.70). Adjusting dietary lutein zeaxanthin attenuated, therefore partially explained, joint association. score. Conclusions Having unhealthy alleles (primarily stages), an (synergistic) manner. regardless genotype.