Crosstalk between endothelial cells and tumor cells in head and neck cancer
作者： Kathleen Gaboardi Neiva
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摘要: It is well known that cancer cells secrete angiogenic factors to recruit and sustain tumor vascular networks. However, little about the effect of endothelial cell- secreted on phenotype behavior cells. The hypothesis underlying this study are able initiate signaling pathways in Here, we observed soluble mediators from primary human dermal microvascular (HDMEC) induce phosphorylation STAT3, Akt, ERK a panel head neck squamous cell carcinoma (HNSCC) (OSCC3, UM-SCC-1, UMSCC-17B, UM-SCC-74A). Gene expression analysis demonstrated interleukin-6 (IL- 6), interleukin-8 (CXCL8), epidermal growth factor (EGF) upregulated co-cultured with HNSCC. Blockade cell-derived IL-6, CXCL8, or EGF by gene silencing neutralizing antibodies inhibited activation cells, respectively. has been Bcl- 2 microvessels patients Bcl-2 induces EGF, providing mechanism
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