Clamping of RNA with PNA enables targeting of microRNA
作者： Alice Ghidini , Helen Bergquist , Merita Murtola , Tanel Punga , Rula Zain
DOI: 10.1039/C6OB00516K
关键词:
摘要: To be able to target microRNAs also at stages where these are in a double stranded or hairpin form we have studied BisPNA designed clamp the and give sufficient affinity allow for strand invasion. We show that complexes more stable with RNA than DNA. In addition, 24-mer (AntimiR) constructs is model of microRNA miR-376b, suggesting PNA-clamping may an effective way targeting microRNAs.
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