Cutting Edge: Spontaneously Ig-Secreting B-1 Cells Violate the Accepted Paradigm for Expression of Differentiation-Associated Transcription Factors

摘要: B-1 cells spontaneously secrete natural Ig that acts as a primary line of defense against infection. A major shortfall in our understanding this key process centers on the molecular mechanisms regulating Ab secretion by cells. Herein, we demonstrate secreting use some aspects recently recognized plasmacytic differentiation program but deviate from it important ways. Specifically, show repressors program, B cell leukemia/lymphoma-6 and paired box gene 5, are reduced cells, stimulated differentiated B-2 Surprisingly, find promoters lymphocyte inducer maturation 1 X-box binding protein 1, not up-regulated contrast to These data operate under is unique differs paradigm associated with Ig-secreting