Fetal toxicity of valsartan and possible reversible adverse side effects.

摘要: BACKGROUND Published cases suggest that the use of angiotensin II receptor antagonists is fetotoxic during third trimester, but not in early pregnancy. CASE: We report a case which adverse fetal effect antagonist treatment was reversed. A woman with chronic hypertension treated valsartan until gestation week (GW) 20, when complete anhydramnios observed. Six days after interruption treatment, amniotic fluid reappeared. It reached normal level at GW 23.5. The plasmatic creatinine and renal ultrasound examination were within limits six-month follow-up. CONCLUSIONS Whereas angiotensin-II-receptor generates severe toxicity, this suggests that, least first half pregnancy, these effects can be Birth Defects Research (Part A) 67:, 2004. © 2004 Wiley-Liss, Inc.