Vitamin C Intake and Risk of Prostate Cancer: The Montreal PROtEuS Study.

摘要: Background: Vitamin C is a reducing agent and free radical scavenger, acting as antioxidant in plasma membranes within cells. Based on these properties, role for vitamin cancer incidence has been suspected. There are yet few large population-based studies focusing prostate cancer, with the preponderant evidence leaning toward absence of an association. Nevertheless, many previous overlooked aggressiveness, well screening detection issues, which could bias potential associations. Methods: The Prostate Cancer Environment Study (PROtEuS) case-control study conducted Montreal, Canada. In-person interviews, 1,916 histologically confirmed cases 1,985 population controls, elicited information wide range socio-demographic, lifestyle, medical factors, including PSA screening. Usual frequency consumption 63 food items two years prior to diagnosis/interview was collected, along use dietary supplements. Odds ratios (OR) 95% confidence intervals (CI) between intake were estimated using logistic or polytomous regression, adjusting confounders. Results: We observed no association intakes (OR upper vs. lower tertile: 0.95, 95%CI 0.77, 1.18), residual method account energy intake, regular supplements and/or multivitamins 0.90, 0.76-1.05), overall cancer. Analyses considering disease restricted subjects recently screened PSA, thereby limiting undiagnosed cancers non-cases, generated results consistent those from main analyses. Conclusion: Our findings document recent supplementation, grade at diagnosis. this, other available evidence, does not seem hold promises regard prevention.