Tailoring hierarchical meso–macroporous 3D scaffolds: from nano to macro

摘要: Bone tissue regeneration requires the use of 3D scaffolds which mimic architecture natural extracellular matrix, creating an adequate microenvironment for bone cell growth. Such need surface properties suitable biological recognition in early stage adhesion, necessary to ensure complete colonization, retained functionality, and subsequently regeneration. Herein, hierarchical based on new hydroxyapatite/mesoporous glass nanocomposite bioceramic (MGHA) exhibiting different scales porosity have been synthesized. These possess: (i) highly ordered mesopores with diameters 10 nm; (ii) macropores 30–80 μm range interconnections 1–10 μm; (iii) large ca. 500 μm. To improve their properties, were modified through direct functionalization amine propyl groups, notably preosteoblast proliferation (2.3 fold), differentiation (4.8 fold) further colonization these scaffolds. The observed enhancement can be related groups favour e.g., nonspecific protein adsorption as was demonstrated by ellipsometry. results suggest that combination structure design modification yields a double increase proliferation, well quadruple differentiation, demonstrating potential materials purposes.