Stimulation by local anesthetics of the metabolism of acidic phospholipids in the rat pineal gland.
作者： Joseph Eichberg , George Hauser
DOI: 10.1016/0006-291X(74)90362-3
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摘要: The efficacy of five local anesthetics in causing stimulation phospholipid metabolism rat pineal gland vitro paralleled their anesthetic potency and decreased the order: dibucaine, tetracaine, cocaine, procaine, lidocaine. When occurred, patterns labeling resembled that produced by propranolol, a β-adrenergic receptor blocking agent with activity. Isotope incorporation into phosphatidylglycerol CDP-diglyceride was markedly enhanced increases phosphatidic acid phosphatidylinositol were also seen. At concentrations 1–10 mM, propranolol inhibited phosphatidylcholine phosphatidylethanolamine more than 90% 32Pi other phospholipids to smaller extent.
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