Lestaurtinib potentiates TRAIL-induced apoptosis in glioma via CHOP-dependent DR5 induction.
作者： Yingxiao Cao , Shiqi Kong , Yuling Xin , Yan Meng , Shuling Shang
DOI: 10.1111/JCMM.15415
关键词:
摘要: Lestaurtinib, also called CEP-701, is an inhibitor of tyrosine kinase, causes haematological remission in patients with AML possessing FLT3-ITD (FLT3 gene) internal tandem duplication and strongly inhibits kinase FLT3. Treatment lestaurtinib modulates various signalling pathways leads to cell growth arrest programmed death several tumour types. However, the effect on glioma remains unclear. In this study, we examined TRAIL interactions cells observed their synergistic activity apoptosis. While U87 U251 showed resistance single treatment, they were sensitized apoptosis induced by presence because increased receptor 5 (DR5) levels through CHOP-dependent manner. We demonstrated using a xenograft model mouse that was absolutely suppressed combined treatment compared or carried out singly. Our findings reveal potential new strategy improve antitumour mechanism dependent CHOP.
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