Epidural morphine provides postoperative pain relief in peripheral vascular and orthopedic surgical patients: a dose-response study.

摘要: A randomized double-blind study compared the dose-response relationship of epidural morphine for postoperative pain relief in two groups patients whose surgical procedures would result either moderate (femoral-popliteal bypass) or severe (total knee replacement) pain. Preservative-free sulphate doses 0, 2, 5, 10 mg a volume ml saline were administered via lumbar catheters. The was 1 hr after last dose intraoperative local anesthetic an effort to achieve pain-free course. significant existed between and both time first required medication 24-hr weighted score. Five provided improvement analgesia with control groups. Further enhancement occurred mg; however, late respiratory depression, demonstrated by increased resting PaCO2 administration, seen only 10-mg Minor complications such as nausea, vomiting, pruritus, urinary retention uncommon did not appear be related dose. We found that 5 long-lasting without serious adverse effects peripheral vascular orthopedic surgery.