Ethnic and geographical distributions of CYP2C19 alleles in the populations of Southeast Asia.

摘要: The genetic polymorphism of drug-metabolizing enzymes has a major influence on the fate xenobiotic substances, whether as drugs or absorbed from environment. Our understanding this is important in order to evaluate predisposition for exposure-related risks and, future, develop individualized drug therapy. Cytochrome P450 play central role metabolism many drugs, chemicals, and carcinogens. Differences activity these are responsible inter-individual variability response toxicity (Bertilsson, 1995). Of cytochrome enzymes, isoform CYP2C19 particular interest because its high inter-racial differences (Goldstein et al., 1997; Kaneko 1999; Griese 2001).