The use of cyclophosphamide, methotrexate, and 5-fluorouracil in the treatment of Merkel cell carcinoma.

摘要: Five patients with advanced Merkel cell carcinoma (MCC) are described. Four regional lymph node involvement and one disseminated skin metastases were treated systemic chemotherapy, including cyclophosphamide, methotrexate, 5-fluorouracil (CMF). The received a median of six cycles CMF (range: 2 to 6), chemotherapy was well tolerated. complete partial response noted. Three alive disease-free at 5, 12, 37 months from the onset chemotherapy. Two died metastatic disease 3 24 appears be an active regimen in treatment locally MCC. Further experience this combination is warranted.