Newly identified structurally disparate modulators of osmosensitive taurine efflux inhibit cell cycle progression

摘要: Abstract FACS analysis and [ 14 C]-taurine efflux were used to determine whether activation of the volume-sensitive organic osmolyte/anion channel plays a role in cell cycle progression. This was achieved by examining effects collection (i) H 1 antagonists tricyclic antidepressants with known inhibitory effect on progression, (ii) oestrogen receptor modulators molecular structures likely confer inhibition channel. Of 13 compounds examined this study, following showed no cytotoxicity 48-h exposure, specifically inhibited osmosensitive taurine (over lactate transport anion exchange) IC 50 values (in μM): fluoxetine, ∼14; fluvoxamine, ∼24; amitriptyline, ∼32; imipramine, mianserin, ∼40. A application these at concentrations significantly increased arrest G0/1 stage ∼10%. The uniformity specificity response elicited strongly reinforces correlation between progression activation.