Insights from engraftable immunodeficient mouse models of hyperinsulinaemia.

摘要: Hyperinsulinaemia, obesity and dyslipidaemia are independent collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID Rag1 −/−) suitable engraftment with human-derived tissue xenografts, effect diet-induced hyperinsulinaemia on human prostate cancer cell line xenograft growth, were investigated. −/−and NOD/SCID HFD-fed mice demonstrated impairments glucose tolerance at 16 23 weeks post weaning. −/− developed significantly higher fasting insulin levels (2.16 ± 1.01 ng/ml, P = 0.01) increased resistance (6.70 ± 1.68 HOMA-IR, compared to low-fat chow-fed (0.71 ± 0.12 ng/ml 2.91 ± 0.42 HOMA-IR). This was not observed strain. Hepatic steatosis more extensive mice. Intramyocellular lipid storage mice, but In LNCaP tumours grew rapidly is first characterisation metabolic HFD studies. We conclude that an appropriate novel model studying relationship between hyperinsulinaemia.