Genetic associations with viral respiratory illnesses and asthma control in children.
作者： D. A. Loisel , G. Du , T. S. Ahluwalia , C. J. Tisler , M. D. Evans
DOI: 10.1111/CEA.12642
关键词:
摘要: BACKGROUND Viral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma. OBJECTIVE We sought to identify variation genes with known antiviral pro-inflammatory functions specific associations more severe viral the risk virus-induced during peak fall season. METHODS The between genetic at 326 SNPs 63 candidate 10 phenotypes related infection asthma control were examined 226 enrolled RhinoGen study. Replication was performed 2128 Copenhagen Prospective Study on Asthma Childhood (COPSAC). Significant further validated using illness an independent sample 122 Origins (COAST) birth cohort RESULTS A significant excess P values smaller than 0.05 observed analysis phenotypes. Polymorphisms 12 significantly associated four showing a enrichment small values. Six those (STAT4, JAK2, MX1, VDR, DDX58, EIF2AK2) also showed COPSAC study or COAST CONCLUSIONS identified factors contributing individual differences childhood Defining mechanisms these may provide insight into pathogenesis
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