Auditory P300 as a predictor of short-term prognosis in subjects at clinical high risk for psychosis

摘要: Abstract Background The aim of this study was to investigate whether P300 could predict the short-term prognosis subjects at clinical high risk (CHR) for psychosis who do not convert psychotic disorder (non-converters). Method CHR were examined with auditory baseline, and their state regularly assessed up 2 years. 45 non-converters divided into remitter non-remitter groups. Repeated-measures analysis variance (ANOVA) performed compare baseline between two Multiple regression used identify factors predicting symptomatic or functional improvement in during follow-up period. Results There no group differences amplitude latency remitters non-remitters. In multiple analysis, Pz (β = 0.206, 95% confidence interval [95CI] = 0.035 0.567, p = 0.028) significantly predicted later amelioration Scale Prodromal Symptoms (SOPS) negative symptoms. Improvement SOPS general symptoms by (β = 0.255, 95CI = 0.065 0.455, p = 0.010) mood stabilizer use (β = 0.199, 95CI = 0.081 4.154, p = 0.042). Conclusions These results indicate that may be a possible predictor non-converters. Our findings support recommendation broader concept assessment guidelines is needed forecast outcome provide appropriate interventions