Auditory P300 amplitude as a state marker for positive symptoms in schizophrenia: cross-sectional and retrospective longitudinal studies

摘要: The amplitude of the P300 component auditory event-related brain potential (ERP) is consistently reduced in schizophrenia. To determine whether this abnormality can be used as a state marker to reflect severity symptoms, we examined both cross-sectionally and longitudinally relationship between symptom patients with For cross-sectional study, ERP was elicited by an oddball paradigm, quantitatively measured means Positive Negative Syndrome Scale 93 schizophrenia or schizophreniform disorder (DSM-III-R). longitudinal psychopathology twice at average interval 238 days for 20 were retrospectively analyzed. data showed that correlated negatively positive but not negative syndrome scale score. also significant correlation changes scores first second tests. In particular, recorded left, right, posterior temporal region significantly studies. These findings support hypotheses left hemisphere symptoms may caused possible left-hemisphere deficit