Myasthenia gravis in the elderly
作者： Mark A. Hellmann , Ronit Mosberg-Galili , Israel Steiner
DOI: 10.1016/J.JNS.2012.10.028
关键词:
摘要: Abstract Objective The objective of the study is to examine clinical, therapeutic and prognostic factors myasthenia gravis (MG) in elderly. Patients methods We reviewed all MG files patients who attended neuro-immunology clinic at Rabin Medical Center, Petah Tikva, Israel from January 1995 until September 2011 for demographic data, presentation, course response treatment. were classified as elderly if disease onset was above 69 years. Results Out 137 with MG, 29 developed after age 69. 108 young had a male:female ratio 0.9:1 whereas eighth ninth decade significant male predominance ratios 2.6:1 4.5:1 respectively. There no difference presenting symptomatology rate sero-negativity when compared early similar. older much less thymic pathology their acetylcholine receptor (AChR) antibody titer lower. This associated better therapy good prognosis. Conclusion not uncommon, more prevalent males, lower AChR antibodies, readily responsive carries
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sci-hub.se 参考文章(23)
Manuel Ramos-Casals, Pilar Brito-Zerón, Alfonso López-Soto, Josep Font, Systemic autoimmune diseases in elderly patients:: Atypical presentation and association with neoplasia Autoimmunity Reviews. ,vol. 3, pp. 376- 382 ,(2004) , 10.1016/J.AUTREV.2003.12.002
Galit Kleiner Fisman, H. Stephen Kott, Myasthenia gravis mimicking stroke in elderly patients Mayo Clinic proceedings. ,vol. 73, pp. 1077- 1078 ,(1998) , 10.4065/73.11.1077
J. M. Aragones, I. Bolibar, X. Bonfill, E. Bufill, A. Mummany, F. Alonso, I. Illa, Myasthenia gravis: A higher than expected incidence in the elderly Neurology. ,vol. 60, pp. 1024- 1026 ,(2003) , 10.1212/01.WNL.0000050461.05432.C5
I. Casetta, E. Groppo, R. Gennaro, E. Cesnik, L. Piccolo, S. Volpato, E. Granieri, Myasthenia gravis: a changing pattern of incidence Journal of Neurology. ,vol. 257, pp. 2015- 2019 ,(2010) , 10.1007/S00415-010-5651-Z
Shigeaki Suzuki, Kimiaki Utsugisawa, Yuriko Nagane, Takashi Satoh, Masataka Kuwana, Norihiro Suzuki, Clinical and immunological differences between early and late-onset myasthenia gravis in Japan. Journal of Neuroimmunology. ,vol. 230, pp. 148- 152 ,(2011) , 10.1016/J.JNEUROIM.2010.10.023
Hiroyuki Murai, Natsumi Yamashita, Makoto Watanabe, Yoshiko Nomura, Masakatsu Motomura, Hiroaki Yoshikawa, Yosikazu Nakamura, Naoki Kawaguchi, Hiroshi Onodera, Shigeru Araga, Noriko Isobe, Masaki Nagai, Jun-ichi Kira, Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey Journal of the Neurological Sciences. ,vol. 305, pp. 97- 102 ,(2011) , 10.1016/J.JNS.2011.03.004
JOHAN A. AARLI, FREDRIK ROMI, GEIR OLVE SKEIE, NILS ERIK GILHUS, Myasthenia Gravis in Individuals over 40 Annals of the New York Academy of Sciences. ,vol. 998, pp. 424- 431 ,(2003) , 10.1196/ANNALS.1254.055
J. M. LINDSTROM, M. E. SEYBOLD, V. A. LENNON, S. WHITTINGHAM, D. D. DUANE, Antibody to acetylcholine receptor in myasthenia gravis Prevalence, clinical correlates, and diagnostic value Neurology. ,vol. 26, pp. 1054- 1054 ,(1976) , 10.1212/WNL.26.11.1054
Amelia Evoli, Anna Paola Batocchi, Cristiana Minisci, Chiara Di Schino, Pietro Tonali, Clinical Characteristics and Prognosis of Myasthenia Gravis in Older People Journal of the American Geriatrics Society. ,vol. 48, pp. 1442- 1448 ,(2000) , 10.1111/J.1532-5415.2000.TB02635.X
G. S. Gronseth, R. J. Barohn, Practice parameter: Thymectomy for autoimmune myasthenia gravis (an evidence-based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology Neurology. ,vol. 55, pp. 7- 15 ,(2000) , 10.1212/WNL.55.1.7