Isolation, purification, and structural features of a polysaccharide from Phellinus linteus and its hypoglycemic effect in alloxan-induced diabetic mice
作者： Chao Zhao , Zunsheng Liao , Xiaoqi Wu , Yanling Liu , Xiaoyan Liu
关键词:
摘要: Phellinus linteus is a medicinal mushroom that has been used in Oriental countries for centuries its antitumor, antioxidant, immunomodulatory, and biological activity on hyperglycemia. A water-soluble crude polysaccharide was extracted using hot water from P. mycelia grown under submerged culture. An orthogonal experiment to optimize the extraction conditions of polysaccharides (PLP). The purified DEAE Sephadex A-50 G-200 chromatography. Fourier transform infrared (FT-IR) spectroscopy nuclear magnetic resonance ((1) H NMR) were investigate structure (PLP-I), revealing it mainly branched-type glycan with both α- β-linkages pyranoid sugar ring conformation. PLP orally administered at 100 mg/kg body weight/d could significantly reduce blood glucose level by 35.60% alloxan-induced diabetic mice. results an oral tolerance test (OGTT) revealed had effect disposal after 28 d treatment. result culture possessed potent hypoglycemic properties. may be useful as functional food additive agent.
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