Levels of Antibody against 11 Staphylococcus aureus Antigens in a Healthy Population

摘要: ABSTRACT Serum samples from 151 healthy individuals aged 15 to 89 years were investigated by enzyme-linked immunosorbent assay (ELISA) for IgG levels against 11 different purified antigens Staphylococcus aureus. Surface antigens, such as teichoic acid, clumping factors A and B, bone sialoprotein binding protein, extracellular proteins, alpha-toxin, lipase, enterotoxin A, toxic shock syndrome toxin, scalded-skin fibrinogen adherence used. The values analyzed in relation the state of nasal carriage at time sampling. There was great individual variation antibody both young elderly subjects. Occurrence S. aureus nares sampling correlated with higher levels, while over 65 age showed slightly lower than younger adults. More expected random probability calculations high several more would be low antigens. Certain proteins had often induced same magnitude individuals, indicating that among these there a tendency respond certain way. Most circulating antibodies tested some “good responders” others “poor responders.” These findings constitute basic knowledge development improved serological diagnostics, immune prophylaxis, prognosis tools, therapy invasive infections.