Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study.

摘要: Recent findings have disclosed the role of UDP-glucuronosyltransferase (UGT) 1A1*28 on haematological toxicity induced by irinotecan (CPT-11), a drug commonly used in treatment metastatic colorectal cancer (mCRC). We investigated pharmacogenomic profile irinotecan-induced gastrointestinal (GI) novel drug-metabolizing enzyme and transporter (DMET) microarray genotyping platform. Twenty-six mCRC patients who had undergone to irinotecan-based chemotherapy were enrolled case (patients experiencing > grade 3 gastrointestinal, toxicity) - control (matched without GI study. A statistically significant difference SNP genotype distribution was found versus group. The homozygous C/C (rs562) ABCC5 gene occurred 6/9 with 1/17 (P=0.0022). G/G (rs425215) ABCG1 7/9 4/17 withou...