Walking speed and brain glucose uptake are uncoupled in patients with multiple sclerosis

摘要: Motor impairments of the upper and lower extremities are common symptoms multiple sclerosis (MS). While some peripheral effects like muscle weakness loss balance have been shown to influence these symptoms, central nervous system activity has not fully elucidated. The purpose this study was determine if alterations in glucose uptake were associated with motor patients sclerosis. Eight (4 men) 8 sex matched healthy controls performed 15 minutes treadmill walking at a self-selected pace, during which ≈ 322 MBq positron emission tomography analogue [18F]-Fluorodeoxyglucose injected. Immediately after cessation walking, participants underwent imaging. Patients MS had FDG 40% brain compared (pFWE-corr -0.75, P < 0.032). Within only 3 regions showed significant correlations: insula (r = -0.74, 0.036), hippocampus -0.72, 0.045), calcarine sulcus -0.77, 0.026). This data suggests that may be due network wide metabolism. Understanding how metabolism altered allow for better measures disability disease status within clinical population.