Inhibition of MAP/ERK kinase prevents IGF-I-induced hypertrophy in rat muscles

作者: Fadia Haddad , Gregory R. Adams

DOI: 10.1152/JAPPLPHYSIOL.00856.2003

关键词:

摘要: Insulin-like growth factor-I (IGF-I) has been shown to stimulate a hypertrophy response in skeletal muscles vivo. In vitro studies have delineated two primary intracellular pathways that appear ...

参考文章(58)
C H Lang, R A Frost, Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells. Minerva Endocrinologica. ,vol. 28, pp. 53- 73 ,(2003)
D. M. Payne, A. J. Rossomando, P. Martino, A. K. Erickson, J. H. Her, J. Shabanowitz, D. F. Hunt, M. J. Weber, T. W. Sturgill, Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). The EMBO Journal. ,vol. 10, pp. 885- 892 ,(1991) , 10.1002/J.1460-2075.1991.TB08021.X
Kathleen A. Martin, John Blenis, Coordinate regulation of translation by the PI 3-kinase and mTOR pathways Advances in Cancer Research. ,vol. 86, pp. 1- 39 ,(2002) , 10.1016/S0065-230X(02)86001-8
Allan G. Gornall, Charles J. Bardawill, Maxima M. David, Determination of serum proteins by means of the biuret reaction. Journal of Biological Chemistry. ,vol. 177, pp. 751- 766 ,(1949) , 10.1016/S0021-9258(18)57021-6
Christian Rommel, Sue C. Bodine, Brian A. Clarke, Roni Rossman, Lorna Nunez, Trevor N. Stitt, George D. Yancopoulos, David J. Glass, Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways Nature Cell Biology. ,vol. 3, pp. 1009- 1013 ,(2001) , 10.1038/NCB1101-1009
Ashwani Khurana, Chinmoy S. Dey, Subtype specific roles of mitogen activated protein kinases in L6E9 skeletal muscle cell differentiation. Molecular and Cellular Biochemistry. ,vol. 238, pp. 27- 39 ,(2002) , 10.1023/A:1019957602038
A Brunetti, I D Goldfine, Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor. Journal of Biological Chemistry. ,vol. 265, pp. 5960- 5963 ,(1990) , 10.1016/S0021-9258(19)39275-0
Hans-Henning Arnold, Barbara Winter, Activated raf kinase inhibits muscle cell differentiation through a MEF2-dependent mechanism. Journal of Cell Science. ,vol. 113, pp. 4211- 4220 ,(2000)
D. L. DeVol, P. Rotwein, J. L. Sadow, J. Novakofski, P. J. Bechtel, Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. American Journal of Physiology-endocrinology and Metabolism. ,vol. 259, ,(1990) , 10.1152/AJPENDO.1990.259.1.E89
Gregory R. Adams, Samuel A. McCue, Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. Journal of Applied Physiology. ,vol. 84, pp. 1716- 1722 ,(1998) , 10.1152/JAPPL.1998.84.5.1716