Subtype specific roles of mitogen activated protein kinases in L6E9 skeletal muscle cell differentiation.
作者： Ashwani Khurana , Chinmoy S. Dey
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摘要: Role of mitogen activated protein kinases (MAPK) in skeletal muscle differentiation is not fully understood. We investigated subtype-specific functions and their interactions, if any, the regulation myogenic L6E9 cells. show inhibition extracellular signal-regulated kinase-1 -2 (ERK-1/-2) activation p38 MAP kinase during rat cells under low serum condition. Inhibition ERK-1/-2 activity dramatically enhanced as was evident from cellular morphology, expression specific marker proteins, suggesting that may be inhibitory to initiation progression differentiation. In contrast, completely prevented differentiation; meaning required till terminal Moreover, activities resulted enhancement whereas culminating abrogation conclude cascades oppositely regulate each other's function(s) thereby regulating
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