Reversible Inactivation of Brain Circuits in Learning and Memory Research

摘要: The field of learning and memory has benefited from reversible brain interventions since they were introduced more than four decades ago., Progress in developing a variety inactivation procedures led to wide array potent tools that now allow us investigate different levels organization processes. As noted the literature, complexity processes involved require complex approach advance understanding relevant neurobiological mechanisms. Although much progress been made at molecular cellular levels, complete picture will be only attained by advancing knowledge functional circuits system level, which it is also recognized as most difficult approach.Limitations available techniques for undergoing lesion may contribute difficulties. This chapter address advantages limitations research on neural substrate level. Thus, results manipulations aimed explore mechanisms not considered because extensive reviews are specific topics.Since seminal work Bures Buresova inactivating regions dissociate sensory associative taste aversion investigating interhemispheric transfer traces, range temporary discrete sites developed applied research. Several centering upon have published past decade show value field.,,, does intend comprehensive review gained using approaches, but representative issues this approach, thus leading better need careful interpretation behavioral based changes induced currently stressed.