Actin-Myosin Spatial Patterns from a Simplified Isotropic Viscoelastic Model

摘要: F-actin networks are involved in cell mechanical processes ranging from motility to endocytosis. The mesoscale architecture of assemblies individual polymers that gives rise micrometer-scale rheological properties is poorly understood, despite numerous vivo and vitro studies. In have been shown organize into spatial patterns when spatially confined, including dense spherical shells inside emulsion droplets. Here we develop a simplified model an isotropic, compressible, viscoelastic material continually assembling disassembling. We demonstrate emerge naturally the strain relaxation rate (corresponding internal network reorganization) slower than disassembly depolymerization). These consistent with recent experiments, collapse central high-density focus either assembly or reduced drugs. Our results how complex spatio-temporal can without distributed force generation, polar alignment polymers, nonuniform regulation by upstream biochemical networks.