A curvilinear Model Approach: Actin Cortex Clustering Due to ATP-induced Myosin Pulls

摘要: Abstract: The actomyosin cortex is involved in a range of many cellular processes like cell division, motility or shaping. To obtain this variety functionalities the membrane-bound actin mesh has to be reconstituted by motor protein myosin. But little known about underlying mechanism, which control different tasks. An vitro study synthetic shown that organizes into spatial clusters for certain ATP concentrations. Here we develop curvilinear model captures viscoelastic material behavior and kinetics myosin cross bridge. Further, suggest formulation active contractile stress produced We demonstrate pattern generated consistent with experimental observations, including clustering due forces an absence contraction low high Additionally show cluster positioning can tuned ATP-gradient.