Recent advances in the pathophysiology and treatment of gastroparesis.

摘要: Gastroparesis is a clinical disorder characterized by upper gastrointestinal symptoms related with delayed gastric emptying of solids and liquids in the absence mechanical obstruction. Diabetes mellitus has been most common cause gastroparesis idiopathic also accounts for third all chronic cases. The important mechanisms gastroparesis, as understood to date, are loss expression neuronal nitric oxide synthase interstitial cells Cajal. However, pathogenesis poorly understood. There have several studies on specific molecules gastroparesis. Additionally, Clinical Research Consortium National Institutes Health achieved promising results regarding pathophysiology As progress made, new drug therapy found. focused this review. Until now, real-world medication options treatment limited. it expected be substantially improved elucidated.