Pluripotency—What Does Cell Polarity Have to Do With It?

摘要: Polarization is a mechanism commonly used by cells to establish asymmetries and create specialized subcellular functional domains. The process of cell polarization especially important during mammalian development, when pluripotent are first established. Pluripotent are, definition, capable giving rise the entire fetus. In addition, stem lines can be derived from embryos created reprogramming differentiated cells. Understanding molecular biological differences between nonpluripotent an research direction in regenerative medicine. This chapter focuses on examining role that plays establishing maintaining pluripotency mouse embryo lines. literature shows that, early embryo, repressed emerging epiblast cells, while apicobasal established multipotent extraembryonic lineages. Since essential for defining which become pluripotent, indirectly responsible embryo. Later, epiblast, polarize just before they exit commence differentiation. Just as multiple stages exist states among lines, ranging naive primed pluripotency. Mirroring embryonic pluripotency, polarity associated with primed, not naive, Therefore, both hallmark decreased developmental potential, suggesting purpose prepare next goal: