Outpatient antimicrobial stewardship targets for treatment of skin and soft-tissue infections.

作者: Preeti Jaggi , Ling Wang , Sean Gleeson , Melissa Moore-Clingenpeel , Joshua R. Watson

DOI: 10.1017/ICE.2018.124

关键词:

摘要: Objective We sought to identify factors associated with long duration and/or non-first-line choice of treatment for pediatric skin and soft-tissue infections (SSTIs). Design Retrospective cohort study. Setting Ambulatory encounter claims Medicaid-insured children lacking chronic medical conditions treated SSTI animal bite injury in Ohio 2014. Methods For all diagnoses, was defined as >7 days. Non-first-line included 2 antimicrobials dispensed on the same calendar day or any not listed Infectious Diseases Society America guidelines. The adjusted odds (1) (2) were calculated patient age, prescriber type, county residence characteristics (ie, rural vs metropolitan area poverty rate). Results Of 10,310 encounters complete data available, prescribed 7,968 (77.3%). most common 10 A 1,030 (10%). Dispensation reason choice, these, trimethoprim-sulfamethoxazole plus a first-generation cephalosporin regimen. Compared pediatricians, ratio significantly lower other primary care specialties. Conversely, nonpediatricians more likely prescribe choice. Patient high-poverty increased both treatment. Conclusions Healthcare may be utilized measure opportunities first-line shorter SSTI.

参考文章(19)
Iara Marques Medeiros, Humberto Saconato, Antibiotic prophylaxis for mammalian bites. Cochrane Database of Systematic Reviews. ,(2001) , 10.1002/14651858.CD001738
Guangrong Zheng, David B. Horton, Agripina G. Deaciuc, Linda P. Dwoskin, Peter A. Crooks, Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorganic & Medicinal Chemistry Letters. ,vol. 16, pp. 5018- 5021 ,(2006) , 10.1016/J.BMCL.2006.07.070
Jeffrey S. Gerber, Priya A. Prasad, Alexander G. Fiks, A. Russell Localio, Robert W. Grundmeier, Louis M. Bell, Richard C. Wasserman, Ron Keren, Theoklis E. Zaoutis, Effect of an Outpatient Antimicrobial Stewardship Intervention on Broad-Spectrum Antibiotic Prescribing by Primary Care Pediatricians: A Randomized Trial JAMA. ,vol. 309, pp. 2345- 2352 ,(2013) , 10.1001/JAMA.2013.6287
Catherine Liu, Arnold Bayer, Sara E. Cosgrove, Robert S. Daum, Scott K. Fridkin, Rachel J. Gorwitz, Sheldon L. Kaplan, Adolf W. Karchmer, Donald P. Levine, Barbara E. Murray, Michael J. Rybak, David A. Talan, Henry F. Chambers, Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children Clinical Infectious Diseases. ,vol. 52, pp. 285- 292 ,(2011) , 10.1093/CID/CIR034
Matthew J. Hepburn, David P. Dooley, Peter J. Skidmore, Michael W. Ellis, William F. Starnes, William C. Hasewinkle, Comparison of Short-Course (5 Days) and Standard (10 Days) Treatment for Uncomplicated Cellulitis Archives of Internal Medicine. ,vol. 164, pp. 1669- 1674 ,(2004) , 10.1001/ARCHINTE.164.15.1669
D. J. Pallin, W. D. Binder, M. B. Allen, M. Lederman, S. Parmar, M. R. Filbin, D. C. Hooper, C. A. Camargo, Clinical Trial: Comparative Effectiveness of Cephalexin Plus Trimethoprim-Sulfamethoxazole Versus Cephalexin Alone for Treatment of Uncomplicated Cellulitis: A Randomized Controlled Trial Clinical Infectious Diseases. ,vol. 56, pp. 1754- 1762 ,(2013) , 10.1093/CID/CIT122
Chris Feudtner, Dimitri A. Christakis, Frederick A. Connell, Pediatric Deaths Attributable to Complex Chronic Conditions: A Population-Based Study of Washington State, 1980–1997 Pediatrics. ,vol. 106, pp. 205- 209 ,(2000)
Jeffrey S. Gerber, Matthew P. Kronman, Rachael K. Ross, Adam L. Hersh, Jason G. Newland, Talene A. Metjian, Theoklis E. Zaoutis, Identifying Targets for Antimicrobial Stewardship in Children's Hospitals Infection Control and Hospital Epidemiology. ,vol. 34, pp. 1252- 1258 ,(2013) , 10.1086/673982
Dennis L. Stevens, Alan L. Bisno, Henry F. Chambers, E. Patchen Dellinger, Ellie J. C. Goldstein, Sherwood L. Gorbach, Jan V. Hirschmann, Sheldon L. Kaplan, Jose G. Montoya, James C. Wade, Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America Clinical Infectious Diseases. ,vol. 59, pp. 147- 159 ,(2014) , 10.1093/CID/CIU296
A. L. Hersh, D. J. Shapiro, A. T. Pavia, S. S. Shah, Antibiotic Prescribing in Ambulatory Pediatrics in the United States Pediatrics. ,vol. 128, pp. 1053- 1061 ,(2011) , 10.1542/PEDS.2011-1337