Simultaneous effects of nicotine, acrolein, and acetaldehyde on osteogenic-induced bone marrow cells cultured on plasma-sprayed titanium implants.
作者： Maria L. Pereira , Maria H. Fernandes , Fernando Peres , João C. Carvalho
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摘要: Purpose: To evaluate the potential interaction/contribution of inductive and deleterious effects tobacco compounds on human osteoblastic cells cultured plasma-sprayed titanium implants exposed to combinations nicotine, acrolein, acetaldehyde. Cell response was assessed as proliferation function. Materials Methods: Titanium implants, seeded with bone marrow‐derived (first subculture), were in osteogenic-inducing conditions for 28 days absence (control) presence assess (1) dose-dependent profile acrolein (0.01 0.12 mmol/L) acetaldehyde (0.1 6 (2) effect simultaneous exposure In later experiments, two different concentrations nicotine (1.2 mmol/L, known have cell behavior, 2.4 reported elicit behavior) acetaldehyde, or both, at a concentration that inhibits 50% (IC
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