Chitinase 3-Like-1 (CHI3L1): A Putative Disease Marker at the Interface of Proteomics and Glycomics
DOI: 10.1080/10408360802334743
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摘要: Chitinase 3-Like-1 (CHI3L1) is a secreted 40 kDa glycoprotein that upregulated in number of human cancers and non-neoplastic disease states characterized by chronic inflammation tissue remodeling. Increased serum levels CHI3L1 parallel severity, poorer prognosis, shorter survival many neoplasias, including the breast, colon, prostate, ovaries, brain, thyroid, lung, liver. also correlates with severity rheumatoid arthritis, osteoarthritis, liver fibrosis, inflammatory bowel disease, bacterial septicemia. arthritis (RA) autoantigen, MHC complexes containing specific peptides have been found RA patients; however, intranasal introduction these same can induce tolerance towards them. nonhydrolytic member chitinase family binds chitin tightly heparin at lower affinity. Interactions type I collagen, CHI3L1's only known protein-bind...
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